NFL Lines Week 1: Point Spreads, Moneyline & O/U

Tom Brady Tampa Bay Buccaneers vs Dallas Cowboys 2021

The 2022 NFL season is approaching fast and we have all the latest Lines for Week 1 right here for you – updated every single day.

Whether you’re looking for point spreads or you are betting straight up, you’ve come to the right place people.

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We still have some preseason games to play, but those are for backups – right? The real thing gets under way Thursday September 8 at SoFi Stadium when the Super Bowl champion Rams host the Super Bowl favorite Bills.

We have seen pretty significant movement on some of the lines already – Buffalo opened a half-point underdog vs the Rams and is now a two-point favorite.

So let’s check out the lines for a terrific first weekend of NFL action:

Week 1 Lines – Point Spreads

Here are the very latest lines and point spreads for Week 1 – updated July 18, 2022:

Thursday September 8, 2022

Buffalo Bills (-2) @ Los Angeles Rams (+2) – 8.20pm ET, NBC

Sunday September 11, 2022

New Orleans Saints (-5.5) @ Atlanta Falcons (+5.5) – 1pm ET, FOX

Baltimore Ravens (-6) @ New York Jets (+6) – 1pm ET, CBS

Cleveland Browns (-1) @ Carolina Panthers (+1) – 1pm ET, CBS

San Francisco 49ers (-6.5) @ Chicago Bears (+6.5) – 1pm ET, FOX

Philadelphia Eagles (-4) @ Detroit Lions (+4) – 1pm ET, FOX

Pittsburgh Steelers (+6.5) @ Cincinnati Bengals (-6.5) – 1pm ET, CBS

Indianapolis Colts (-8) @ Houston Texans (+8) – 1pm ET, CBS

New England Patriots (+2.5) @ Miami Dolphins (-2.5) – 1pm ET, CBS

Jacksonville Jaguars (+4) @ Washington Commanders (-4) – 1pm ET, FOX

Kansas City Chiefs (-3) @ Arizona Cardinals (+3) – 4.25pm ET, CBS

Green Bay Packers (-2) @ Minnesota Vikings (+2) – 4.25pm ET, FOX

Las Vegas Raiders (+3.5) @ Los Angeles Chargers (-3.5) – 4.25pm ET, CBS

New York Giants (+6.5) @ Tennessee Titans (-6.5) – 4.25pm ET, FOX

Tampa Bay Buccaneers (-2) @ Dallas Cowboys (+2) – 8.20pm ET, NBC

Monday September 12, 2022

Denver Broncos (-5) @ Seattle Seahawks (+5) – 8.15pm ET, ESPN/ABC

Week 1 Lines – Moneyline

If you want to bet straight up with no spread on Week 1, here are the early best odds available:

GameRoadHome
Buffalo Bills @ Los Angeles Rams-125+115
New Orleans Saints @ Atlanta Falcons-215+190
Cleveland Browns @ Carolina Panthers-105-105
Baltimore Ravens @ New York Jets-230+220
San Francisco 49ers @ Chicago Bears-255+230
Philadelphia Eagles @ Detroit Lions-190+172
Indianapolis Colts @ Houston Texans-330+300
Pittsburgh Steelers @ Cincinnati Bengals+245-270
Jacksonville Jaguars @ Washington Commanders+170-190
New England Patriots @ Miami Dolphins+125-140
Kansas City Chiefs @ Arizona Cardinals-155+140
Green Bay Packers @ Minnesota Vikings-130+115
Las Vegas Raiders @ Los Angeles Chargers+168-170
New York Giants @ Tennessee Titans+240-260
Tampa Bay Buccaneers @ Dallas Cowboys-125+114
Denver Broncos @ Seattle Seahawks-190+180

Week 1 Lines – Over/Under

Buying or selling total points in a game is one of THE best bets on an NFL Sunday – here are the Week 1 lines:

GameOver/Under
Buffalo Bills @ Los Angeles Rams51.5
New Orleans Saints @ Atlanta Falcons41.5
Cleveland Browns @ Carolina Panthers41.5
Baltimore Ravens @ New York Jets45
San Francisco 49ers @ Chicago Bears42
Philadelphia Eagles @ Detroit Lions46.5
Indianapolis Colts @ Houston Texans44
Pittsburgh Steelers @ Cincinnati Bengals44.5
Jacksonville Jaguars @ Washington Commanders43.5
New England Patriots @ Miami Dolphins44.5
Kansas City Chiefs @ Arizona Cardinals53
Green Bay Packers @ Minnesota Vikings49
Las Vegas Raiders @ Los Angeles Chargers52
New York Giants @ Tennessee Titans43.5
Tampa Bay Buccaneers @ Dallas Cowboys52
Denver Broncos @ Seattle Seahawks41.5

NFL Week 1 Predictions

You can check out our way too early Week 1 NFL predictions by clicking here.

NFL Betting explained

Okay so not all of you are likely experienced bettors, so how about we enlighten you? We’ve put together a full guide on how the odds work, and you can check it out here.

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