NFL Parlay Picks: Get ready for the 2022 season!

The full 2022 NFL schedule is now official and the countdown is on to the big kickoff in September, and we will have parlay picks for every single game weekend. We cannot wait…

On May 12 we finally got to find out who plays who in 2022, and when. Excitement is at fever pitch.

We have had free agency and the Draft, and now we are on to minicamps and then training camp before we finally get to the real deal. Thursday September 8 when the Super Bowl Champion Los Angeles Rams host the Super Bowl favorite Buffalo Bills in a terrific season opener at SoFi Stadium.

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You can also check out our best NFL prop bets and our NFL picks against the spread.

Week 1 Parlay Picks & Best Bets

The games commence, like we said, on Thursday September 8, 2022 and there are some terrific games scheduled. We’ll preview them all and pick out the best bets to include in our Week 1 Parlay:

Buffalo Bills vs Los Angeles Rams (Thursday September 8, 6.30pm ET, NBC)

The big kickoff on Sunday Night Football as the Super Bowl champion hosts the Super Bowl favorite – get the popcorn ready.

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When online sportsbooks released their Week 1 lines once the schedule was made official, they had the Rams as a 1-point favorite. Could not be closer…

New Orleans Saints @ Atlanta Falcons (Sunday September 11, 1pm ET, FOX)

The Falcons are in rebuild mode, the Saints are the absolute opposite – they still believe they have a championship in this group.

Surprising then that the Saints are only a 3.5-point favorite in the early going. Doesn’t see a great deal for all that horse trading during the recent College Draft.

Baltimore Ravens @ New York Jets (Sunday September 11, 1pm ET, CBS)

A brave new world for the New York Jets after what was widely acclaimed as a terrific Draft – they finished up with three first-round picks remember as well as a RB in Breece Hall who was seen as a first-round talent.

Despite all of that, Zach Wilson and co are currently a 4.5-point underdog to start their season with a W.

Cleveland Browns @ Carolina Panthers (Sunday September 11, 1pm ET, CBS)

The beginning of the Deshaun Watson era in Cleveland and they open with a game that has W written all over it.

Carolina HC Matt Rhule looks to be firmly on the hotseat heading into Year 3 of his seven-year deal – still without a clear answer at quarterback.

Sportsbooks have the Browns as a 4.5-point favorite right now.

San Francisco @ Chicago Bears (Sunday September 11, 1pm ET, FOX)

The Niners must start finding out if much-heralded rookie Trey Lance is the answer under center during his sophomore year – this is a roster built to go deep into the postseason.

The Bears meanwhile did pretty much nothing to improve their roster in the offseason – doesn’t say much about their belief in their sophomore QB Justin Fields.

The Niners, not surprisingly, are a firm favorite at -6.5 right now.

Philadelphia Eagles @ Detroit Lions (Sunday September 11, 1pm ET, FOX)

Philly had a terrific offseason, drafting well and picking up Tennessee Titans WR A.J. Brown in a blockbusting trade. It also snagged an extra first-round pick for the 2023 Draft. Jalen Hurts is on notice…

Detroit overachieved in 2021, one of the best teams in the NFL against the spread despite its low talent level. A good Draft should mean better days ahead, but the Eagles are a 4-point favorite.

Indianapolis Colts @ Houston Texans (Sunday September 11, 1pm ET, CBS)

After the failed Carson Wentz experiment, the Colts swing for the fences again at QB with that trade for Matt Ryan – pretty sweet acquisition for just a third-round pick.

The Texans have finally started the long road back to what they hope will be relevance after acquiring that bounty in the Deshaun Watson trade. It will take time though and Indy is an eight (EIGHT) point favorite.

New England Patriots @ Miami Dolphins (Sunday September 11, 1pm ET, CBS)

Bill Belichick and the Pats were much quieter this offseason after a spending spree in 2021, and it will be fascinating to see if they can improve on that wildcard berth.

The Dolphins meanwhile put QB Tua Tagovailoa on notice by giving him a new toy in Tyreek Hill and significantly improving his offensive line. He’d better be the man to get this team into the postseason in 2022.

Miami starts as a 3-point favorite.

Jacksonville Jaguars @ Washington Commanders (Sunday September 11, 1pm ET, FOX)

The Jags spent big in free agency after the disastrous tenure of HC Urban Meyer, and the hire of Doug Pederson to replace him will hopefully get QB Trevor Lawrence back on track.

Washington meanwhile has a pretty nice roster but everything will likely rest on QB Carson Wentz after the Commanders traded to get him from Indianapolis.

Washington starts with a 4.5-point edge.

Pittsburgh Steelers @ Cincinnati Bengals (Sunday September 11, 1pm ET, CBS)

A huge AFC North matchup as the Bengals start what they hope will be the road back to the Super Bowl.

Cincy has made massive upgrades to its offensive line while the Steelers will start the post-Ben Roethlisberger era at QB. Will it be FA signing Mitch Trubisky or rookie Kenny Pickett here?

Cincy has opened up a 6.5-point favorite.

Kansas City Chiefs @ Arizona Cardinals (Sunday September 11, 4.25pm ET, CBS)

Terrific match up this, with Patrick Mahomes vs Kyler Murray the dish of the day.

The Chiefs aced the draft while the Cards still have a ton of question marks. How much will the departure of Tyreek Hill hurt the Chiefs offense though?

KC starts as a three-point favorite.

Las Vegas Raiders @ Los Angeles Chargers (Sunday September 11, 4.25pm ET, CBS)

It doesn’t seem like five minutes since these two teams were fighting out that terrific Week 18 ‘win and you’re in’ showdown in the shadow of The Strip in Sin City.

This should be a beauty with the Chargers going all in on 2022 and the Raiders acquiring Davante Adams from Green Bay. The Chargers open up a four-point favorite with homefield advantage.

New York Giants @ Tennessee Titans (Sunday September 11, 4.25pm ET, FOX)

After a terrible couple of years the Giants look much improved after an excellent Draft, while the Titans are coming off a year where they overachieved to clinch the #1 seed in the AFC.

No surprise the Titans are a firm favorite, with a 6.5-point edge.

Green Bay Packers @ Minnesota Vikings (Sunday September 11, 4.25pm ET, FOX)

Aaron Rodgers is back, but he has very few weapons to throw to after the departure of Davante Adams to Las Vegas.

The Vikes meanwhile start a new era with Kevin O’Connell at HC, can he really make that high-powered offense start to hum? GB is a slight favorite in the early going at -1.5.

Tampa Bay Buccaneers @ Dallas Cowboys (Sunday September 11, 8.20pm ET, NBC)

An absolute beauty in Arlington as the unretired Tom Brady goes up against Dak Prescott and America’s Team.

The Cowboys could not have had a more troubled offseason, and they will start a 2-point underdog here.

Denver Broncos @ Seattle Seahawks (Monday September 12, 8.15pm ET, ESPN/ABC)

Another beauty to crown the debut of new broadcast team Joe Buck and Troy Aikman on Monday Night Football as Russell Wilson returns to Seattle after that blockbusting trade to Denver.

Seattle is now in rebuild mode after the departures of Wilson and LB Bobby Wagner, and they will start a four-point underdog here.

What is a parlay?

A parlay is a bet where winning and losing comes down to a number of selections – not just one.

So for example on an NFL Sunday you could put 6 teams into one parlay bet. All your wagers need to come up for you to win the parlay bet.

The odds multiply as your selections (hopefully) win, a bit like compound interest from your bank.

So the positive thing about a parlay is that as well as being terrific fun – you can win really big.

The downside is you have to get multiple things right to win. Getting one bet right is not easy – how about 3, 4, 5 or maybe even more.

What is the best NFL parlay strategy?

The best strategy when you are doing a parlay is play it safe and simple. Do not go for crazy big odds – remember everything has to hit for you so don’t take risks. And don’t go for exotic bets or markets. Spread or money line is good.

Our advice would be to pick a max of five selections that you are very confident in and don’t even think about the odds unless they are absolutely terrible. The fact they all multiply means you’ll get a nice payout if they all come up.

The reason we’re suggesting this strategy is that online sportsbooks just LOVE parlays. Simply because they are tough to hit on. That should tell you all you need to know. Like we say, go for surefire winners – not hopeful long shots.

Another thing we’d advise as a fun play is to pick the winners of each NFL division before the season starts and put them in a parlay. Eight teams yes, but gives you interest (hopefully) throughout the season. And could be a terrific payoff to buy you a nice holiday in the offseason.

How much does a $100 parlay pay?

Well, that really depends on what the odds are.

There are parlay calculators out there that help you work out the odds. But we’ll give you a couple of examples

Example 2: A $100 parlay where your three selections are +200, +400 and +600

You would win $10,400 and with your $100 stake back too, your total payout would be $10,500

Example 2: A $100 parlay where your four selections are +150, -120 and +210

You would win $1320,82 and with your stake back too your total payout would be $1420.82

What can I parlay NFL?

The answer is pretty much anything you want. And a ton of sportsbooks now offer same-game parlay functions to make it easy. Worth bearing in mind though that same-game parlays often have pretty bad odds because some of the outcomes affect each other. For example if a quarterback throws 4 TD passes, pretty good chance his team wins…

Where is the NFL Parlay?

Every online sportsbooks offers parlay bets, and you can build some really nice wagers off the back of them.